Solid State Bioreactor

Over 25 years production experience

Fer-bio: Your Trusted Chinese Manufacturer of Airlift Fermenters

In the domestic biological equipment field, Fer-bio focuses on the research and development and production of air-lift fermenters, with its products covering all scenarios – from laboratory small-scale trial devices and pilot-scale equipment to industrial-grade large tanks, as well as animal/plant cell reactors, single-use reaction systems and liquid distribution equipment.

Whether it’s a 0.1L micro-tank or a 1000KL giant device, Ferbio can customize them and also provides full-service support: from process design, commissioning to intelligent solutions. It once helped a vaccine enterprise solve a problem in the fermentation process.

The team is solid and consists of engineers with over ten years of experience, specializing in fermentation processes, equipment design and chemical engineering respectively. We also hire well-known professors in the industry as advisors to help overcome technical difficulties.

Fer-bio adheres to the principle of “customer first”, not only selling equipment but also helping customers generate real benefits – for instance, shortening the fermentation cycle of pharmaceutical factories and ensuring the stability of trial production data for research institutions. As a result, it has accumulated many repeat customers.

Introduction to Solid State Bioreactor

Fer-bio solid state bioreactor is used in pharmaceutical, beverage, enzymic preparation, bio pesticide, feed, etc. with advantages saved investment, good aseptic performance, saved operation environment, simple maintenance, no easy pollution to the environment, etc. This solid state bioreactor volume range from 5L-50KL.

Cases

50L solid state bioreactor and 30L mechanical stirring bioreactor

Fer-bio 50L solid state bioreactor and 30L mechanical stirring bioreactor

Fer-bio 100L solid state bioreactor BLBIO-SS

solid state fermentation technology

Fer-bio 200L solid state bioreactor BLBIO-SS

20KL-Solid-state-fermenter-system-application-site-BLBIO-20KL

20KL Solid state Bioreactor System BLBIO-SS

Know More About Solid State Bioreactor

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Utility System

Cleaning, maintenance and care of the fermenter tank

Cleaning

  1. The fermenter tank body is the place that comes into direct contact with the material. The degree of its surface finish and the cleanliness of its internal components are factors that directly affect the contamination. Therefore, the tank body and related equipment must be cleaned in time after each fermentation and before reuse. When cleaning, attention should be paid to the electrical components and electrode interfaces, and water and moisture should not be allowed to enter.
  2. PH and DO electrodes should be taken out before cleaning and maintained according to their requirements.
  3. The tank can be cleaned together with water intake, air intake, motor stirring and heating. If it cannot be cleaned after multiple water changes, the top cover should be opened and the internal parts of the tank should be brushed with a soft brush. The method is as follows: control the switch and the power switch, remove the top cover electrode, motor and its connection plug. Unplug the air intake hose condenser quick connector and remove the air intake filter upper hose and connector; remove the top cover together with the stirring vertically upward, and place it horizontally on a flat table, pad it well, do not hit the shaft and impeller, and use a neutral detergent to brush the tank body and internal parts.
  4. Note: When moving and cleaning the tank cover, only the shaft sleeve or top cover can be grasped, and the stirring shaft, impeller and other easily deformed parts cannot be grasped. While cleaning, the tank and outlet valve and other O-rings should be checked. If deformation, aging, scratches, etc. are found, they should be replaced in time. After cleaning and reinstalling, the surface and tank rack should be wiped dry with a rag. Tighten the six fastening screws of the tank cover, use balanced force and pay attention to the balance of the gap between the tank and the tank seat. Be especially careful when cleaning the glass fermentation tank, and do not collide during disassembly and assembly; when tightening the fastening screws of the tank cover, the force must be balanced and pay attention to the balance of the gap to avoid damaging the glass tank body.

Maintenance of the stirring system

  • The stirring system includes the stirring shaft, stirring paddle, mechanical seal. Bearings, couplings and motors, etc.
  • Daily maintenance: Regularly check the operation of the stirring shaft, the heating of the motor and the emission of abnormal noise, and regularly check whether the relevant bolts are loose.
  • Check the wear of the mechanical seal every year to ensure the normal operation of the mechanical seal and avoid unnecessary contamination.
  • If a double-end mechanical seal is used, always pay attention to the changes in the sterile water level. If the liquid level drops, it means that the seal gap is leaking, which should be handled immediately after the fermentation is completed.
  • Check the wear of the oil seal and the carbon brush of the motor, as well as the wear of the oil seal and the bearing every year.

Maintenance and care of sterilized air system

    • The sterilized air system includes air compressor, coarse filter, fine filter, diaphragm valve and air distributor, etc.
    • In daily maintenance, attention should be paid to the operation of the air compressor. During the fermentation process, the drain valve of the air storage tank should be drained twice a day. Maintenance and care of the filter The sterilization temperature should be controlled below 125℃
    • During the sterilization process, attention should be paid to the sterilization temperature of the filter should be controlled below 125℃. Because the filter material will fall off at too high a temperature, the binder will make the filter ineffective.
    • Replacement of filter element.
    • Because the air contains a lot of dust, the micropores of the filter element will gradually become blocked after the filter has been used for a period of time. On the one hand, this will increase the resistance, causing serious lack of air flow and increased air pressure drop, thereby affecting the ventilation volume, and may cause bacterial contamination. At this time, it needs to be replaced.
    • Due to the large differences in air quality in various places, there is no accurate service life, which can generally reach more than 6 months. The replacement standard is that the minimum air flow is not less than 1.5 times the volume of the tank. (The pressure difference between the pressure reducer outlet and the tank pressure is not less than 1kg/cm2)
    • After each fermentation, the air distributor needs to be cleaned. If the properties of the fermentation liquid are similar to water, water can be added to the tank and then compressed air can be passed through for cleaning. If the fermentation liquid is viscous or contains fine particles, it is best to remove the air distributor, unscrew the plug, and rinse with water. At the same time, ensure that the small holes are ventilated smoothly.

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Our Advantages

Extensive experience and expertise

We have many years of experience in the industry and accumulated a wealthof professional knowledge to provide customers with the best quality products and services.

Diverse product lines

We provide products in the field of bioreactor (fermenter) andcomplete control system to provide customers with a full range of solutions.

Strict quality control.

We have always adhered to strict quality management and technological innovation to ensure that our products are always in the leading positionin the industry.

Customer first service concept.

We always stand on the customer's point of view, starting from the customer's needs, to provide customers with the best solution. No matter what customers need, we will meet their needs with a professional attitude and high-quality products.