Your Reliable Chinese Industrial Fermenter Manufacturer : Ferbio
Ferbio Biotechnology is a leading industrial fermenter manufacturer based in China, specializing in the design and production of bioreactors for laboratory, pilot-scale, and industrial applications. Our product portfolio includes fermenters, animal cell bioreactors, plant cell bioreactors, single-use bioreactors, liquid dispensing systems, and disposable reactors.
Ferbio is capable of manufacturing bioreactors ranging from 0.1 L to 1000 KL in volume and provides comprehensive technical services and intelligent, customized process solutions.
With a strong team of experienced fermentation process engineers, biochemical equipment specialists, and chemical technology experts—along with renowned scholars serving as technical consultants—Ferbio is committed to creating lasting value for customers. Guided by our core value of customer-centric innovation, we continuously strive to deliver excellence and reliability in every solution we provide.
What Is Stainless Steeel Industrial fermenter?
The industrial fermenter is designed for large-scale production and features a sterile seed transfer system, enabling seamless inoculation from smaller bioreactors to larger ones. It supports a continuous fermentation process, effectively reducing production time and improving efficiency.
Each project can be custom-designed to meet specific process requirements. The system includes on-site sterilization and sterilization-in-place (SIP) functions, along with automated program control for all key fermentation parameters, ensuring easy operation, convenient cleaning, and space efficiency.
Standard models monitor and control pH, DO, foam, temperature, agitation, and gas flow, while the control panel interface is available in English, Chinese, and Russian.


Industrial Fermenter Can Meet Various Production Needs
The industrial fermenter is designed to meet diverse fermentation needs across various industries, including food, feed, pharmaceuticals, and more. It supports multiple fermentation modes such as batch and fed-batch, and is suitable for the cultivation of bacteria, yeast, microorganisms, animal cells, and algae.
Each fermenter features a 10-inch color touch screen displaying all key measurements and control parameters. Standard configurations include four peristaltic pumps for acid, alkali, antifoam, and medium addition. The system provides automatic control of pH, DO, temperature, agitation, and antifoam, with gas control available in both manual and automatic (mass flow meter) modes.
All fermentation data are recorded with historical trend curves and can be exported via USB for analysis and documentation.
Ferbio offers customized design and configuration options to meet specific process and production requirements.
We can customize industrial fermenter
Industrial fermenter have more optional: Remote control, Mass flow meter, gas O2/N2/CO2, Exhaust gas (O2/CO2) analysis, Level sensor, Turbidity(OD) sensor, ORP sensor, Glucose detection, Weight system, Live cell sensor(Biomass), Variable speed pump, Printing, 15” color touch screen, Siemens screen, program open setting etc..

Know More About Industrial Fermenter
| Parameter | Description |
| Total volume | 5L,10L,15L,20L,30L,50L,100L,200L,500L,1000L, 5KL, 50KL, 200KL etc. |
| Working volume | 30%~70% |
| Tank | Jacket tank, made by SS316 and SS304, tank design pressure 0.3Mpa, jacket design pressure 0.35Mpa, polishing 0.4-0.6um, ratio of diameter and height is 1:2.2-2.5 |
| Stirring system | Mechanical drive on the top/bottom or Magnetic drive on the top, 3pcs height adjustable six-blade paddle Stir speed: 50~1000rpm/50-400rpm |
| Sterilization | Sterilize in place(SIP), auto control by program |
| Clean | Clean in place (CIP) by spray ball |
| Gas control | Control by rotor meter, air flow 1 vvm |
| Feeding | Automatically feeding by peristaltic pump |
| Anti-foam control | Automatically add antifoam by peristaltic pump |
| Temperature control | Auto-control, electric heating range: water source add 5℃ to 70℃ |
| PH control | PH 2.00-12.00±0.1, auto-control adding acid/base by peristaltic pump, pH sensor from Hamilton/Mettler, Switzerland. |
| Do control | 0-150±3% displaying precision 0.1%, DO sensor from Hamilton/Mettler, Switzerland. DO coupling with agitation, oxygen. |
| Sampling | Sampling valve, can sterilization separately, manual |
| Harvest | Zero dead zone bottom valve(Gemu/Burket,Germany), can sterilization separately, manual/auto |
| Lid lift system | 30L-500L have lid lift system, 700-1000L have human hole. |
| Pressure | Auto control, BD Germany pressure transmitter |
| Exhaust | Have condenser before exhaust, control by diagram valve / Proportional control valve. |
| Control parameters | 10 or 15 inch touch screen , Siemens PLC with control parameters (stirring, pH, DO, temperature, feeding, alarm, gas etc.), data analysis, data record, data output, language(RU/EN/CN) and other customized functions |
| Optional configuration | We can customize the parameters of industrial fermenter according to customer needs,such as remote control, Mass flow meter(auto control gas), O2/N2/CO2, gas flow 2vvm, gas(CO2) exhaust analysis, Level sensor, Turbidity(OD) sensor, ORP sensor, Weight system, Live cell sensor(Biomass), Printing, Siemens touch screen, Double mechanical seal, 4-Valves-group for feeding, Bottom valve auto discharge, ASME certificate, CSA certificate, Batch culture, Seed transfer, etc. |


The following picture shows the production workshop of Bailun.
Supporting Equipment
The refrigeration system of a chiller unit consists of four basic parts: compressor, condenser, throttle, and evaporator. Connect the four major components in a certain order using copper pipes to form a closed system, which is filled with a certain amount of refrigerant.
The compressor sucks in low-temperature and low-pressure Freon gas from the evaporator, compresses it into high-temperature and high-pressure Freon gas, and then flows through a thermal expansion valve (capillary tube), throttling it into a low-temperature and low-pressure Freon liquid two-phase object. Then, the low-temperature and low-pressure Freon liquid absorbs heat from indoor air in the evaporator, and the cycle of compression condensation throttling evaporation is repeated.
The Ferbio steam generator uses well-known imported accessories, which are corrosion-resistant and finely crafted. Fast steam production in one minute, with a thermal efficiency of up to 100.27%. Clean steam, sufficient gas production, can provide stable steam for a long time, ensuring the required heat energy during the drying process. Advanced vertical cross flow structure, using 12Cr1MoVG high-pressure boiler steel and stainless steel laser fins with extremely high heat transfer efficiency, no explosion risk, safer equipment, and better steam quality.
Ferbio air compressor is an oil-free and silent air compressor equipped with a domestically produced powerful air pump and a gas tank with built-in anti-corrosion coating. It has a high cost performance and is used as a supporting equipment for bioreactors. Has the following characteristics:
● Independently produce machine heads and components;
The machine is equipped with multiple automatic protection systems for safer use;
● Easy to operate, ready to use upon power connection, automated design, no need for dedicated personnel to operate the work;
●Low noise during work, original oil-free piston system, high efficiency, low loss, and clean gas discharge;
●Optional double-layer vacuum drying and filtering equipment to meet the supply of high-purity air source and protect user equipment;
Other Products
Cleaning, maintenance and care of the fermenter tank
Cleaning
- The fermenter tank body is the place that comes into direct contact with the material. The degree of its surface finish and the cleanliness of its internal components are factors that directly affect the contamination. Therefore, the tank body and related equipment must be cleaned in time after each fermentation and before reuse. When cleaning, attention should be paid to the electrical components and electrode interfaces, and water and moisture should not be allowed to enter.
- PH and DO electrodes should be taken out before cleaning and maintained according to their requirements.
- The tank can be cleaned together with water intake, air intake, motor stirring and heating. If it cannot be cleaned after multiple water changes, the top cover should be opened and the internal parts of the tank should be brushed with a soft brush. The method is as follows: control the switch and the power switch, remove the top cover electrode, motor and its connection plug. Unplug the air intake hose condenser quick connector and remove the air intake filter upper hose and connector; remove the top cover together with the stirring vertically upward, and place it horizontally on a flat table, pad it well, do not hit the shaft and impeller, and use a neutral detergent to brush the tank body and internal parts.
- Note: When moving and cleaning the tank cover, only the shaft sleeve or top cover can be grasped, and the stirring shaft, impeller and other easily deformed parts cannot be grasped. While cleaning, the tank and outlet valve and other O-rings should be checked. If deformation, aging, scratches, etc. are found, they should be replaced in time. After cleaning and reinstalling, the surface and tank rack should be wiped dry with a rag. Tighten the six fastening screws of the tank cover, use balanced force and pay attention to the balance of the gap between the tank and the tank seat. Be especially careful when cleaning the glass fermentation tank, and do not collide during disassembly and assembly; when tightening the fastening screws of the tank cover, the force must be balanced and pay attention to the balance of the gap to avoid damaging the glass tank body.
Maintenance of the stirring system
- The stirring system includes the stirring shaft, stirring paddle, mechanical seal. Bearings, couplings and motors, etc.
- Daily maintenance: Regularly check the operation of the stirring shaft, the heating of the motor and the emission of abnormal noise, and regularly check whether the relevant bolts are loose.
- Check the wear of the mechanical seal every year to ensure the normal operation of the mechanical seal and avoid unnecessary contamination.
- If a double-end mechanical seal is used, always pay attention to the changes in the sterile water level. If the liquid level drops, it means that the seal gap is leaking, which should be handled immediately after the fermentation is completed.
- Check the wear of the oil seal and the carbon brush of the motor, as well as the wear of the oil seal and the bearing every year.
Maintenance and care of sterilized air system
- The sterilized air system includes air compressor, coarse filter, fine filter, diaphragm valve and air distributor, etc.
- In daily maintenance, attention should be paid to the operation of the air compressor. During the fermentation process, the drain valve of the air storage tank should be drained twice a day. Maintenance and care of the filter The sterilization temperature should be controlled below 125℃
- During the sterilization process, attention should be paid to the sterilization temperature of the filter should be controlled below 125℃. Because the filter material will fall off at too high a temperature, the binder will make the filter ineffective.
- Replacement of filter element.
- Because the air contains a lot of dust, the micropores of the filter element will gradually become blocked after the filter has been used for a period of time. On the one hand, this will increase the resistance, causing serious lack of air flow and increased air pressure drop, thereby affecting the ventilation volume, and may cause bacterial contamination. At this time, it needs to be replaced.
- Due to the large differences in air quality in various places, there is no accurate service life, which can generally reach more than 6 months. The replacement standard is that the minimum air flow is not less than 1.5 times the volume of the tank. (The pressure difference between the pressure reducer outlet and the tank pressure is not less than 1kg/cm2)
- After each fermentation, the air distributor needs to be cleaned. If the properties of the fermentation liquid are similar to water, water can be added to the tank and then compressed air can be passed through for cleaning. If the fermentation liquid is viscous or contains fine particles, it is best to remove the air distributor, unscrew the plug, and rinse with water. At the same time, ensure that the small holes are ventilated smoothly.
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Our Advantages
Extensive experience and expertise
We have many years of experience in the industry and accumulated a wealthof professional knowledge to provide customers with the best quality products and services.
Diverse product lines
We provide products in the field of bioreactor (fermenter) andcomplete control system to provide customers with a full range of solutions.
Strict quality control.
We have always adhered to strict quality management and technological innovation to ensure that our products are always in the leading positionin the industry.
Customer first service concept.
We always stand on the customer's point of view, starting from the customer's needs, to provide customers with the best solution. No matter what customers need, we will meet their needs with a professional attitude and high-quality products.
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